Joseph Fraietta, PhD: Arming CAR T Cells for the Solid Tumor Battlefield

Year Funded: 2019

“I absolutely love my job!” says Joseph Fraietta, PhD. “It’s about the people – the patients and their lives and their families.”

Dr. Fraietta recalls being in grad school, working in infectious disease and HIV immunology, and reading about the game-changing CAR T-cell therapy developed by ACGT Research Fellow Carl June,

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Stephen Gottschalk, MD: I Never Need to Ask Myself Why I’m Here

Year Funded: 2019

“Because sarcomas can occur in different parts of the body and account for only about 15 percent of all childhood cancers, treatments and protocols have been challenging to pinpoint,” says Stephen Gottschalk, MD, chair of Bone Marrow Transplantation and Cellular Therapy at St. Jude Children’s Research Hospital (Memphis,

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Greg Michael Delgoffe, PhD: The Problem with Chemo, Radiation and Surgery

Year Funded: 2016

Greg Michael Delgoffe, PhD: The Problem with Chemo, Radiation and Surgery

“Cancer doesn’t stop. Cancer cells are constantly dividing and proliferating,” says Greg Michael Delgoffe, PhD, of the University of Pittsburgh Department of Immunology (Pittsburgh, Pa.). “The problem with chemo, radiation and surgery is that they don’t always get it all [cancer cells].

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Crystal Mackall, MD: Unleashing the Hounds

Year Funded: 2015

Crystal Mackall: Unleashing the Hounds

“To use a patient’s own immune system to fight cancer, we need to turn that patient’s CAR T cells into bloodhounds. We train them to sniff out and kill cancer cells,” says Crystal Mackall, MD, of Stanford University (Stanford,

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