Yvonne Chen, PhD: Building Better CARs

Years Funded: 2016-2019

High-Throughput Screening of High-Performance Chimeric Antigen Receptors
Yvonne Chen, PhD, of the Department of Microbiology, Immunology and Molecular Genetics, and the Department of Chemical Biomolecular Engineering at the University of California, Los Angeles, organized an ambitious high-throughput screening (HTS) initiative to identify high-performing chimeric antigen receptors (CARs) from thousands of CAR variants. After shifting her research methodology to testing constructs in animal models, three structural parameters were determined to have the most impact on CAR design plus a promising new CAR targeting a B-cell lymphoma antigen (CD20) emerged.

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