2018

David Reardon, MD

Dana-Farber Cancer Institute, Boston, Massachusetts Professor of Medicine

Research Focus: CAR T cell therapy

Cancer Type: Brain cancer

Award: Clinical Investigator

Dr. Reardon is leading laboratory research into CAR T cell therapy for a deadly brain cancer, based on the FDA-approved treatment for leukemia and lymphoma. This form of immunology has yet to be an option for cancers like glioblastoma because proteins associated with solid tumors often also exist in normal tissues. In addition, the cancer is determined to reject immune system intervention. Dr. Reardon has developed a unique two-step approach to knock out the built-in resistance and bind the tumor with an antibody recognized by T cells to sustain immunity. Results should lead to a clinical trial.

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