Jian Yu, PhD

Jian Yu, PhD
University of Pittsburgh

Year Funded:

Lung Cancer

Oncogenesis: using PUMA protein as a novel target to selectively encourage apoptosis in lung cancer.

Lung cancer remains one of the greatest public health threats, despite advancement in the understanding of molecular genetics. We have been accumulating preliminary data and developing reagents for this project for the past two years, and we are encouraged by the early results of using PUMA, a protein, as a novel target to selectively encourage apoptosis, cell death, in lung cancer cells. With this funding, we will be able to expand the research into animal model trials, and it is our hope that these efforts will allow us to examine the feasibility of moving PUMA gene therapy towards clinical trials. 

Academic Profile

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Jian Yu, PhD
Professor of Pathology
UPMC Hillman Cancer Center
Research Pavilion Suite 2.26H
5117 Centre Avenue
Pittsburgh, PA 15213