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FDA approves first cancer cell therapy for solid tumor.

…Accelerated Approval for Advanced Melanoma. Iovance Biotherapeutics. Retrieved from: https://ir.iovance.com/news-releases/news-release-details/iovances-amtagvitm-lifileucel-receives-us-fda-accelerated/. Accessed: 02/20/2024. Key Statistics for Melanoma Skin Cancer. American Cancer Society. Retrieved from: https://www.cancer.org/cancer/types/melanoma-skin-cancer/about/key-statistics.html. Accessed: 02/20/2024. FDA grants accelerated approval…

Cancer gene therapy: Understanding the basics

…and Drug Administration. Retrieved from: https://www.fda.gov/consumers/consumer-updates/what-gene-therapy-how-does-it-work. Accessed: 01/25/2022. How CAR T-Cell Therapy Works. Dana-Farber Cancer Institute. Retrieved from: https://www.dana-farber.org/cellular-therapies-program/car-t-cell-therapy/how-car-t-cell-therapy-works/. Accessed: 01/25/2022. Gene Therapy. Mayo Clinic. Retrieved from: https://www.mayoclinic.org/tests-procedures/gene-therapy/about/pac-20384619. Accessed: 03/07/2022….

Brown

…this behavior that Dr. Brown intends to stop by equipping a patient’s own T cells to kill immune-suppressing macrophages in tumors. https://www.youtube.com/watch?v=UPPy4KwNUFM Dr. Brown’s creative strategy is rooted in the…

Who We Are

https://www.youtube.com/watch?v=mTOE8rgFqJA   Executive Leadership The Alliance for Cancer Gene Therapy staff are dedicated to the success of our mission and goals. See our Executive Leadership   Board of Directors These…

June

…create “serial killer” T cells (CAR T cells) to battle cancerous tumors. https://www.youtube.com/watch?v=A3o4isEFF2s Their research success led directly to the first life-saving CAR T-cell therapies for treatment of certain children…

Chiocca

…migrating to the tumor – much more than with other therapies. We think this is a way to stimulate the immune system to begin attacking the tumor.” https://www.youtube.com/watch?v=qs5ec251jq0 ACGT-funded research…

Approved CAR T Therapies

Search and destroy. Cancer cells make themselves invisible to T cells and this is what allows them to thrive. CAR T-cell therapies make it possible to detect the undetectable in…

Summit Registration Confirmation

…Floor, New York, NY 10016 SCHEDULE: 8:30 – 6:00 pm RECOMMENDED HOTELS Park South Hotel parksouthhotel.com 124 E 28th St New York, NY 10016 Hotel Giraffe hotelgiraffe.com 365 Park Ave…

Can side effects of CAR T-cell therapy be better controlled?

…Cell Therapy for Relapsed or Refractory Lymphoma. ASH. Retrieved from: https://ash.confex.com/ash/2021/webprogram/Paper150431.html. Accessed: 12/29/2021. Blockade or deletion of IFNg reduces macrophage activation without compromising CAR-T function in hematologic malignancies. Blood Cancer…

ACGT SAC member improving analysis of glioblastoma response to virotherapy

…GET UPDATES ABOUT ACGT RESEARCHERS Page sources Quantitative imaging of apoptosis following oncolytic virotherapy by magnetic resonance fingerprinting aided by deep learning. Nature Biomedical Engineering. Retrieved from: https://www.nature.com/articles/s41551-021-00809-7. Accessed: 01/14/2022….

ACGT Research Fellow boosts CAR T-cell effectiveness using gene editing

…exhaustion and enhances antitumor activity. Science Translational Medicine. Retrieved from: https://www.science.org/doi/10.1126/scitranslmed.abh0272. Accessed: 01/24/2022. Knocking out specific gene prevents T-cell exhaustion, boosts CAR T-cell responses. MedicalXpress. Retrieved from: https://medicalxpress.com/news/2021-11-specific-gene-t-cell-exhaustion-boosts.html. Accessed: 01/24/2022….

ACGT Fellow Sidi Chen, PhD uncovers gene to enhance CAR T cells

…from: https://news.yale.edu/2022/03/10/yale-scientists-supercharge-cancer-fighting-t-cells. Accessed: 03/11/2022. A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy. Cell Metabolism. Retrieved from: https://www.cell.com/cell-metabolism/pdf/S1550-4131(22)00053-5.pdf. Accessed: 03/11/2022….

What to learn From Senator Harry Reid’s fight With pancreatic cancer

…doing better by then. His improved health was thanks to a clinical trial run by the biotech company ImmunityBio. The former Senate Majority Leader received a combination of  three therapies using the immune system to seek out and kill cancer without the toxic impact…

Researchers find success using herpes virus for glioblastoma

…sources Study supports virotherapy as a potential treatment for brain tumors. University of Alabama Birmingham. Retrieved from: https://www.uab.edu/news/research/item/12589-study-supports-virotherapy-as-a-potential-treatment-for-brain-tumors. Accessed: 02/08/2022. Long-term survival with glioblastoma multiforme. Oxford Academic. Retrieved from: https://academic.oup.com/brain/article/130/10/2596/376628….

Powell

…T-cell therapy he hopes will achieve dramatic results. “There’s an old saying that I like,” says Powell. “All patients deserve an optimistic doctor.” https://www.youtube.com/watch?v=1xRSTH9IbsM Unlike traditional chemotherapy and radiation, Dr….

Yescarta impresses as first-line therapy option for large B-cell lymphoma

…patients. Page sources With Approval for Axi-cel in Second-line on the Horizon, CAR T-Cell Therapy Poised to Enter New Phase. American Journal of Managed Care. Retrieved from: https://www.ajmc.com/view/with-approval-for-axi-cel-in-second-line-on-the-horizon-car-t-cell-therapy-poised-to-enter-new-phase. Accessed: 02/16/2022….

Mackall

…https://www.youtube.com/watch?v=vk1IQs7k45w The Alliance-funded portion of Dr. Mackall’s research was complex and mission-critical to advancing the GD2 strategy out of the laboratory and into clinical trials. In the process, Dr. Mackall…