…Accelerated Approval for Advanced Melanoma. Iovance Biotherapeutics. Retrieved from: https://ir.iovance.com/news-releases/news-release-details/iovances-amtagvitm-lifileucel-receives-us-fda-accelerated/. Accessed: 02/20/2024. Key Statistics for Melanoma Skin Cancer. American Cancer Society. Retrieved from: https://www.cancer.org/cancer/types/melanoma-skin-cancer/about/key-statistics.html. Accessed: 02/20/2024. FDA grants accelerated approval…
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…and Drug Administration. Retrieved from: https://www.fda.gov/consumers/consumer-updates/what-gene-therapy-how-does-it-work. Accessed: 01/25/2022. How CAR T-Cell Therapy Works. Dana-Farber Cancer Institute. Retrieved from: https://www.dana-farber.org/cellular-therapies-program/car-t-cell-therapy/how-car-t-cell-therapy-works/. Accessed: 01/25/2022. Gene Therapy. Mayo Clinic. Retrieved from: https://www.mayoclinic.org/tests-procedures/gene-therapy/about/pac-20384619. Accessed: 03/07/2022….
…this behavior that Dr. Brown intends to stop by equipping a patient’s own T cells to kill immune-suppressing macrophages in tumors. https://www.youtube.com/watch?v=UPPy4KwNUFM Dr. Brown’s creative strategy is rooted in the…
https://www.youtube.com/watch?v=mTOE8rgFqJA Executive Leadership The Alliance for Cancer Gene Therapy staff are dedicated to the success of our mission and goals. See our Executive Leadership Board of Directors These…
…create “serial killer” T cells (CAR T cells) to battle cancerous tumors. https://www.youtube.com/watch?v=A3o4isEFF2s Their research success led directly to the first life-saving CAR T-cell therapies for treatment of certain children…
…migrating to the tumor – much more than with other therapies. We think this is a way to stimulate the immune system to begin attacking the tumor.” https://www.youtube.com/watch?v=qs5ec251jq0 ACGT-funded research…
Search and destroy. Cancer cells make themselves invisible to T cells and this is what allows them to thrive. CAR T-cell therapies make it possible to detect the undetectable in…
…Floor, New York, NY 10016 SCHEDULE: 8:30 – 6:00 pm RECOMMENDED HOTELS Park South Hotel parksouthhotel.com 124 E 28th St New York, NY 10016 Hotel Giraffe hotelgiraffe.com 365 Park Ave…
…Cell Therapy for Relapsed or Refractory Lymphoma. ASH. Retrieved from: https://ash.confex.com/ash/2021/webprogram/Paper150431.html. Accessed: 12/29/2021. Blockade or deletion of IFNg reduces macrophage activation without compromising CAR-T function in hematologic malignancies. Blood Cancer…
…today to further advance our research to find cures for cancer. Page sources A Cancer Treatment Makes Leukemia Vanish, But Creates More Mysteries. New York Times. Retrieved from: https://www.nytimes.com/2022/02/02/health/leukemia-car-t-immunotherapy.html. Accessed:…
…GET UPDATES ABOUT ACGT RESEARCHERS Page sources Quantitative imaging of apoptosis following oncolytic virotherapy by magnetic resonance fingerprinting aided by deep learning. Nature Biomedical Engineering. Retrieved from: https://www.nature.com/articles/s41551-021-00809-7. Accessed: 01/14/2022….
…exhaustion and enhances antitumor activity. Science Translational Medicine. Retrieved from: https://www.science.org/doi/10.1126/scitranslmed.abh0272. Accessed: 01/24/2022. Knocking out specific gene prevents T-cell exhaustion, boosts CAR T-cell responses. MedicalXpress. Retrieved from: https://medicalxpress.com/news/2021-11-specific-gene-t-cell-exhaustion-boosts.html. Accessed: 01/24/2022….
…from: https://news.yale.edu/2022/03/10/yale-scientists-supercharge-cancer-fighting-t-cells. Accessed: 03/11/2022. A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy. Cell Metabolism. Retrieved from: https://www.cell.com/cell-metabolism/pdf/S1550-4131(22)00053-5.pdf. Accessed: 03/11/2022….
…cancer and ovarian cancer. Lung cancer and ovarian cancer are two common types of solid tumors. Lung cancer is the second most common type of cancer (behind breast cancer). Ovarian…
…oncolytic virus to treat glioblastoma. Mustang Bio, a clinical-stage biopharmaceutical company, is developing the combination therapy and sponsoring the phase 1 study. The combination study is supported by two separate…
…doing better by then. His improved health was thanks to a clinical trial run by the biotech company ImmunityBio. The former Senate Majority Leader received a combination of three therapies using the immune system to seek out and kill cancer without the toxic impact…
…sources Study supports virotherapy as a potential treatment for brain tumors. University of Alabama Birmingham. Retrieved from: https://www.uab.edu/news/research/item/12589-study-supports-virotherapy-as-a-potential-treatment-for-brain-tumors. Accessed: 02/08/2022. Long-term survival with glioblastoma multiforme. Oxford Academic. Retrieved from: https://academic.oup.com/brain/article/130/10/2596/376628….
…T-cell therapy he hopes will achieve dramatic results. “There’s an old saying that I like,” says Powell. “All patients deserve an optimistic doctor.” https://www.youtube.com/watch?v=1xRSTH9IbsM Unlike traditional chemotherapy and radiation, Dr….
…patients. Page sources With Approval for Axi-cel in Second-line on the Horizon, CAR T-Cell Therapy Poised to Enter New Phase. American Journal of Managed Care. Retrieved from: https://www.ajmc.com/view/with-approval-for-axi-cel-in-second-line-on-the-horizon-car-t-cell-therapy-poised-to-enter-new-phase. Accessed: 02/16/2022….
…https://www.youtube.com/watch?v=vk1IQs7k45w The Alliance-funded portion of Dr. Mackall’s research was complex and mission-critical to advancing the GD2 strategy out of the laboratory and into clinical trials. In the process, Dr. Mackall…