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Mackall

…1 clinical trial testing the therapy – called “SNIP-CAR” – in patients with B7H3-expressing tumors. https://www.youtube.com/watch?v=vRNdPcN5nD4 The remote-control feature is intended to provide more command of how the engineered cells…

Explaining the new CAR T-cell therapy approved for multiple myeloma

…Stage for Multiple Myeloma. American Cancer Society. Retrieved from: https://www.cancer.org/cancer/multiple-myeloma/detection-diagnosis-staging/survival-rates.html. Accessed: 03/01/2022. FDA Approves Cilta-cel to Treat R/R Multiple Myeloma. American Journal of Managed Care. Retrieved from: https://www.ajmc.com/view/fda-approves-cilta-cel-to-treat-r-r-multiple-myeloma. Accessed: 03/01/2022….

Cell and gene therapy for brain cancer: How ACGT is advancing research

…04/03/2023. Brain Tumor: Statistics. American Society of Clinical Oncology. Retrieved from: https://www.cancer.net/cancer-types/brain-tumor/statistics. Accessed: 04/03/2023. What Are the Most Common Types of Brain Tumors? Penn Medicine. Retrieved from: https://www.pennmedicine.org/updates/blogs/neuroscience-blog/2018/november/what-are-the-most-common-types-of-brain-tumors. Accessed: 04/03/2023….

Summit Registration Confirmation

…Floor, New York, NY 10016 SCHEDULE: 8:30 – 6:00 pm RECOMMENDED HOTELS Park South Hotel parksouthhotel.com 124 E 28th St New York, NY 10016 Hotel Giraffe hotelgiraffe.com 365 Park Ave…

Laurie Adami

…monoclonal antibody treatment combined with chemotherapy, which was FDA-approved to treat follicular lymphoma.  After the six cycles, Laurie had clean scans and thought she was in complete remission. She returned…

ACGT Research Fellow boosts CAR T-cell effectiveness using gene editing

…exhaustion and enhances antitumor activity. Science Translational Medicine. Retrieved from: https://www.science.org/doi/10.1126/scitranslmed.abh0272. Accessed: 01/24/2022. Knocking out specific gene prevents T-cell exhaustion, boosts CAR T-cell responses. MedicalXpress. Retrieved from: https://medicalxpress.com/news/2021-11-specific-gene-t-cell-exhaustion-boosts.html. Accessed: 01/24/2022….

Could diabetes discovery improve CAR T cells for pancreatic cancer?

…Cancer Immunotherapy, Sloan Kettering Institute Scientists Say. Memorial Sloan Kettering Cancer Center. Retrieved from: https://www.mskcc.org/news/discovery-stem-cell-type-1-diabetes-holds-potential-improving-cancer-immunotherapy-sloan-kettering-institute-scientists-say. Accessed: 12/6/2021. Survival Rates for Pancreatic Cancer. American Cancer Society. Retrieved from: https://www.cancer.org/cancer/pancreatic-cancer/detection-diagnosis-staging/survival-rates.html. Accessed: 01/04/2021….

City of Hope works to develop allogeneic CAR cell therapy for pancreatic cancer

…Accessed: 01/21/2022. City of Hope and CytoImmune announce study demonstrating novel off-the-shelf chimeric antigen receptor (CAR) natural killer (NK) cell-based therapy against pancreatic cancer. BusinessWire. Retrieved from: https://www.businesswire.com/news/home/20220118005366/en/City-of-Hope-and-CytoImmune-announce-study-demonstrating-novel-off-the-shelf-chimeric-antigen-receptor-CAR-natural-killer-NK-cell-based-therapy-against-pancreatic-cancer. Accessed: 01/22/2022….

FDA approves first cancer cell therapy for solid tumor.

…Accelerated Approval for Advanced Melanoma. Iovance Biotherapeutics. Retrieved from: https://ir.iovance.com/news-releases/news-release-details/iovances-amtagvitm-lifileucel-receives-us-fda-accelerated/. Accessed: 02/20/2024. Key Statistics for Melanoma Skin Cancer. American Cancer Society. Retrieved from: https://www.cancer.org/cancer/types/melanoma-skin-cancer/about/key-statistics.html. Accessed: 02/20/2024. FDA grants accelerated approval…

Cancer gene therapy: Understanding the basics

…and Drug Administration. Retrieved from: https://www.fda.gov/consumers/consumer-updates/what-gene-therapy-how-does-it-work. Accessed: 01/25/2022. How CAR T-Cell Therapy Works. Dana-Farber Cancer Institute. Retrieved from: https://www.dana-farber.org/cellular-therapies-program/car-t-cell-therapy/how-car-t-cell-therapy-works/. Accessed: 01/25/2022. Gene Therapy. Mayo Clinic. Retrieved from: https://www.mayoclinic.org/tests-procedures/gene-therapy/about/pac-20384619. Accessed: 03/07/2022….

June

…create “serial killer” T cells (CAR T cells) to battle cancerous tumors. https://www.youtube.com/watch?v=A3o4isEFF2s Their research success led directly to the first life-saving CAR T-cell therapies for treatment of certain children…

Who We Are

https://www.youtube.com/watch?v=mTOE8rgFqJA   Executive Leadership The Alliance for Cancer Gene Therapy staff are dedicated to the success of our mission and goals. See our Executive Leadership   Board of Directors These…

Brown

…this behavior that Dr. Brown intends to stop by equipping a patient’s own T cells to kill immune-suppressing macrophages in tumors. https://www.youtube.com/watch?v=UPPy4KwNUFM Dr. Brown’s creative strategy is rooted in the…

Approved Cell and Gene Therapies

…either by itself or in a combination, and if your cancer is BRAF mutation-positive, a BRAF-inhibitor drug with or without a MEK inhibitor drug that has also stopped working. Tecelra…

Ryman

…metastasized cancer cells. We intend first to develop and test these agents in cultured cells. We will then test and optimize the ability of the virus to cure prostate cancer….

Ahmed

…cell suppressive factors. Thus, Aim 3 will test in preclinical models our hypothesis that combining STAT3 inhibition with HER2-specific T cells will more effectively eradicate GBMs than T cells alone.  …

Cell and gene therapy highlights from 2023.

…an oncolytic virus to fight glioblastoma, which is the most common brain tumor. These grants will help the scientific community learn more about the potential of cell and gene therapies…

CAR T-cell therapy leads to incredible remission rate for children with cancer

…gene therapy research. Page sources New study achieves 99 percent remission in children who relapse with most common childhood cancer. St. Jude Children’s Research Hospital. Retrieved from: https://www.stjude.org/inspire/news/new-study-achieves-99-percent-remission-in-children-who-relapse-with-most-common-childhood-cancer.html. Accessed: 12/19/2022….

Can side effects of CAR T-cell therapy be better controlled?

…therapy for cancers. UMass Chan Medical School. Retrieved from: https://www.umassmed.edu/news/news-archives/2021/12/han-lab-developing-light-activated-immune-cell-therapy-for-cancers/. Accessed: 12/29/2021. A Phase II Study of Prophylactic Anakinra to Prevent CRS and Neurotoxicity in Patients Receiving CD19 CAR T…