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ACGT Fellow Sidi Chen, PhD uncovers gene to enhance CAR T cells

…from: https://news.yale.edu/2022/03/10/yale-scientists-supercharge-cancer-fighting-t-cells. Accessed: 03/11/2022. A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy. Cell Metabolism. Retrieved from: https://www.cell.com/cell-metabolism/pdf/S1550-4131(22)00053-5.pdf. Accessed: 03/11/2022….

Examining a unique cell and gene therapy for ovarian cancer

…for our monthly email newsletter and other communications. Page sources Anixa Biosciences Announces Treatment of First Patient in its Ovarian Cancer CAR-T Clinical Trial. Biospace. Retrieved from: https://www.biospace.com/article/releases/anixa-biosciences-announces-treatment-of-first-patient-in-its-ovarian-cancer-car-t-clinical-trial/. Accessed: 09/09/2022….

Researchers find success using herpes virus for glioblastoma

…sources Study supports virotherapy as a potential treatment for brain tumors. University of Alabama Birmingham. Retrieved from: https://www.uab.edu/news/research/item/12589-study-supports-virotherapy-as-a-potential-treatment-for-brain-tumors. Accessed: 02/08/2022. Long-term survival with glioblastoma multiforme. Oxford Academic. Retrieved from: https://academic.oup.com/brain/article/130/10/2596/376628….

Yescarta impresses as first-line therapy option for large B-cell lymphoma

…patients. Page sources With Approval for Axi-cel in Second-line on the Horizon, CAR T-Cell Therapy Poised to Enter New Phase. American Journal of Managed Care. Retrieved from: https://www.ajmc.com/view/with-approval-for-axi-cel-in-second-line-on-the-horizon-car-t-cell-therapy-poised-to-enter-new-phase. Accessed: 02/16/2022….

ACGT SAC member improving analysis of glioblastoma response to virotherapy

…GET UPDATES ABOUT ACGT RESEARCHERS Page sources Quantitative imaging of apoptosis following oncolytic virotherapy by magnetic resonance fingerprinting aided by deep learning. Nature Biomedical Engineering. Retrieved from: https://www.nature.com/articles/s41551-021-00809-7. Accessed: 01/14/2022….

Biotech Funding Program

https://www.youtube.com/watch?v=9-KNerTWgRs&authuser=0 With guidance from our Scientific Advisory Council and Board of Directors, the organization considers funding projects with robust scientific foundations and clearly defined paths to the clinic and the…

What We Fund

https://www.youtube.com/watch?v=lIumUed7ZPI With success in overcoming blood cancers established, our current funding priorities focus on new curative strategies for the most difficult-to-treat solid tumor cancers – glioblastoma, a brain cancer, and…

Powell

…T-cell therapy he hopes will achieve dramatic results. “There’s an old saying that I like,” says Powell. “All patients deserve an optimistic doctor.” https://www.youtube.com/watch?v=1xRSTH9IbsM Unlike traditional chemotherapy and radiation, Dr….

Comparing Immune checkpoint inhibitors and CAR T-cell therapies

…Cancer Research Institute. Retrieved from: https://www.cancerresearch.org/en-us/immunotherapy/treatment-types/immunomodulators-checkpoint-inhibitors. Accessed: 03/18/2022. Side Effects of Immunotherapy. American Society of Clinical Oncology. Retrieved from: https://www.cancer.net/navigating-cancer-care/how-cancer-treated/immunotherapy-and-vaccines/side-effects-immunotherapy. Accessed: 03/22/2022. PTP1B Is an Intracellular Checkpoint that Limits T-cell…

Why we need to advance cell and gene therapy research for pancreatic cancer.

…on the ACGT website. Page sources Key Statistics for Pancreatic Cancer. American Cancer Society. Retrieved from: https://www.cancer.org/cancer/types/pancreatic-cancer/about/key-statistics.html. Accessed: 09/29/2023. Pancreatic Cancer Prognosis. Johns Hopkins Medicine. Retrieved from: https://www.hopkinsmedicine.org/health/conditions-and-diseases/pancreatic-cancer/pancreatic-cancer-prognosis. Accessed: 09/29/2023….

Frequently asked questions about TIL therapy for cancer.

…6 things to know. National Cancer Institute. Retrieved from: https://www.cancer.gov/news-events/cancer-currents-blog/2024/fda-amtagvi-til-therapy-melanoma. Accessed: 03/15/2024. Breakthrough Treatment for Solid Tumors With TIL Therapy. University of Maryland Medical Center. Retrieved from: https://www.umms.org/ummc/pros/physician-briefs/cancer/immunotherapy/til-therapy. Accessed: 03/15/2024….

Kasahara

When Noriyuki Kasahara, MD, PhD, was a student in medical school, he watched his aunt lay in a coma for nearly a year, dying of glioblastoma. It was then that…