Podack
…not find any indication of immune activation including a complete absence of killer cells (cytotoxic T cells) that could recognize and kill the tumors. Lung tumors are therefore classified as…
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Our Impact On Cancer
…razor-sharp focus on raising money to fund solid tumor research projects and continuing an important new collaboration in cell therapy for brain cancer. Read the Latest Impact Report Meet…
Glorioso
…simplex virus (oHSV) whose use in treatment of late-stage melanoma achieved a significant “cure” rate (~50%) when administered in combination with antibodies that enhance tumor rejection. Here we propose to…
Thorne
Probably the greatest limitation to the application of gene therapy for the treatment of cancer remains the difficulty in delivering a therapeutic gene efficiently and selectively to its tumor target….
Fraietta
…therapies with CAR T cells, involving innovative combinations of metabolic as well as epigenetic modifiers of the aforementioned checkpoint switches and genetic technology to be tested in rigorous preclinical models….
Stephan
…but vaccines developed from them commonly fail because the immunized patients do not have enough T cells that are inherently able to recognize the predicted antigens. The goal of our…
Davidoff
…major specific aims are: Aim 1: To complete the demonstration of anti-tumor synergy between AAV-mediated local delivery of IFN-B and adjuvant cytotoxic therapy, in relevant brain tumor models. Aim 2:…
Dranoff
…secrete RGE, using comparable techniques as for the GM-CSF secreting K562 cells, and then to obtain an investigator sponsored IND that will support clinical evaluation of this combinatorial vaccination strategy…
Hung
…developed by Cell Genesys. The mesothelin-expressing Listeria-based vaccine is currently being tested in patients with pancreatic cancer and mesothelioma, while the GM-CSF secreting K562 cell line is being tested in…
Lane
Since most human tumors must recruit new blood vessels in order to grow and move, anti-angiogenic therapies have been viewed as a potential complement to more traditional cancer treatments. We…
Lesniak
Glioblastoma multiforme (GBM) represents the most common primary malignant tumor of the adult central nervous system. The median survival after surgical intervention alone is approximately six months and the addition…
O’Shea
Most chemotherapies in general use are little more than DNA poisons that slow down tumor growth but do not ultimately cure patients. Chemotherapy also has devastating side effects, which is…
Bell
Effective brain cancer therapies remain a critically unmet need in human healthcare. Advances in surgical, radiation and chemotherapeutic treatments have done little to change patients’ outcomes in the past 30…
Pollack S
…in a very unique way, by using mice that had been engineered to have human immune system components. We are now ready, for the first time, to combine both genetically…
Sadelain
This clinical translational proposal aimed to assess the therapeutic potential of genetically targeted T cells in the treatment of leukemia and lymphoma. The introduction of genes that code for tumor-specific…
Stegh
…mechanism by which double-stranded RNA induces gene silencing by targeting complementary mRNA for degradation, was awarded a Nobel Prize in 2006. Early studies indicated that RNAi has the potential to…
Tamada
…targeted to tumor cells will be utilized for tumor-selective LIGHT expression in vivo. Successful completion of this project will strongly support the potency of LIGHT as a target for advanced…
Vonderheide
A promising approach in cancer treatment is to vaccinate patients against molecules expressed by cancer in hopes of starting or awakening an immune response that will kill tumor cells. One…
Cattaneo
…with modulatable cytotoxicity, and viruses with a targeted envelope. Eventually we will combine the characteristics of the most effective viruses into a ‘second generation’ virus that is armed and targeted….
Chiocca
…The virus that we have tested in mice with brain tumors is named MGH2 and we now plan to perform preclinical toxicology studies requested by the FDA before proceeding to…